204.4 📌 章末速蚘

  • HPV: dsDNA papillomavirus, > 200 types, 40 anogenital
  • High-risk types: 16, 18 → ~ 70% cervical CA; 31, 33, 45, 52, 58 etc.
  • Low-risk: 6, 11 → genital warts + RRP
  • Diseases: cervical CA, anal CA, oropharyngeal CA (rising), vulvar / vaginal / penile, warts, RRP
  • E6 (p53) + E7 (Rb) = oncogenes
  • Vaccine Gardasil 9 (9vHPV): 9 types, 2-dose 9-14, 3-dose 15-26; shared 27-45

  • 95% efficacy preventing HPV infection + pre-cancer

  • Cervical screening (USPSTF 2024): HPV primary q5y preferred 25-65
  • ANCHOR 2024: AIN 2-3 treatment reduces anal CA in HIV+
  • Pembrolizumab + chemo for advanced cervical CA (KEYNOTE-826)
  • WHO 2030: 90/70/90 cervical CA elimination
  • Treatment: genital warts (imiquimod / cryotherapy / surgical); cervical pre-cancer (LEEP / cone); cancer (surgery + chemoradiation + ICI)