213 Ch 213. Hepatitis B Virus

dsDNA hepadnavirus; 296M chronic carriers globally; hepatocellular carcinoma + cirrhosis primary morbidity; vaccine prevents acute infection + cancer; chronic Tx: TDF/TAF/entecavir; HBV cure paradigm shift: bulevirtide, GalNAc-siRNA, capsid assembly modulators, therapeutic vaccines (2024-2025 clinical trials)。