241 Ch 241. Antifungal Agents

5 major classes: polyenes (amphotericin B), azoles (fluconazole/voriconazole/posaconazole/isavuconazole), echinocandins (caspofungin/micafungin/anidulafungin/rezafungin), flucytosine (5-FC), terbinafine; 22E 新藥 rezafungin (once-weekly echinocandin, FDA 2023), ibrexafungerp (oral triterpenoid, FDA 2021), olorofim (orotomide, Phase 3); azole resistance + Candida auris challenges。