ð åèç
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è â Classic Rashes Numbering
- 1st measles, 2nd scarlet fever, 3rd rubella, 5th erythema infectiosum (parvovirus B19), 6th roseola (HHV-6)
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è â Slapped Cheek
- Children with bright red cheek rash
- Reticular trunk + extremity rash follows
- B19 = 5th disease
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è â Receptor
- P antigen (globoside) on erythrocyte progenitors â tropism
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è â Aplastic Crisis
- Sickle cell, hereditary spherocytosis, thalassemia + B19 â catastrophic anemia
- Transfusion + supportive
- Low reticulocyte
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è â Hydrops Fetalis
- 1-2 trimester maternal B19 â vertical â fetal erythroid + heart failure
- MCA Doppler PSV > 1.5 MoM
- Intrauterine transfusion
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è â Pure Red Cell Aplasia in Immunocompromise
- HIV, HSCT, transplant
- Sustained viremia, âlantern cellsâ in marrow
- IVIG
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è â Contagious Window
- Before rash appears (viremic phase)
- Not contagious once rash visible
- Implication: schools éåžž exposure after contagious period