223.4 📌 章末速記

223.4.0.0.1 Lassa Fever

• Arenaviridae ssRNA
• W Africa endemic, Mastomys natalensis rat reservoir
• 80% mild, 20% severe (fever + facial edema + pharyngitis + bleeding)
• SNHL 30% survivors
• Pregnancy 3rd trimester 80% mortality
• Ribavirin (early) + supportive
• Vaccines in trials (MVA-LASV Phase 3)

223.4.0.0.2 LCMV

• House mouse reservoir
• Congenital → mimics CMV (microcephaly + hydrocephalus + chorioretinitis + calcifications)
• Transplant transmission severe
• Aseptic meningitis postnatal
• Supportive; ribavirin off-label

223.4.0.0.3 S. American HF

• Junin (Argentine) — Candid #1 vaccine
• Machupo, Guanarito, Sabia
• Ribavirin + supportive

223.4.0.0.4 All Arenaviruses

• Rodent reservoirs
• BSL-4 lab
• Ribavirin early start = best outcome
• Endemic countries surveillance + healthcare worker safety
• Travel medicine awareness