219 Ch 219. Dengue Virus

4 serotypes (DENV-1, 2, 3, 4); Aedes aegypti + A. albopictus vector; tropical worldwide; second infection with different serotype = ↑ severe dengue risk (ADE — antibody-dependent enhancement); 2022 Qdenga vaccine (Takeda) + 2015 Dengvaxia (Sanofi); 22E expansion of dengue range due climate change — Taiwan endemic季節 outbreaks every 2-3 yr。