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Pathogens
- S. pneumoniae (most common bacterial)
- M. pneumoniae, C. pneumoniae (atypicals, young)
- Legionella (severe, water, atypical features + hyponatremia)
- H. influenzae (COPD)
- S. aureus (post-flu, IVDU, MRSA)
- Klebsiella (alcoholic, currant jelly sputum)
- Viral (influenza, RSV, COVID, rhinovirus) â increasingly recognized
CURB-65 (MEMORIZE)
- Confusion + Urea > 7 + RR ⥠30 + BP < 90/60 + age ⥠65
- 0-1: outpatient
- 2: hospitalize short
- ⥠3: full admit, consider ICU at ⥠4
IDSA/ATS Severe CAP (⥠1 major OR ⥠3 minor)
- Major: mechanical ventilation, septic shock
- Minor: RR ⥠30, PaO2/FiO2 †250, multilobar, confusion, uremia, leukopenia, thrombocytopenia, hypothermia, hypotension
Treatment Algorithm
- Outpatient healthy: amoxicillin / doxy / macrolide
- Outpatient comorbid: amox-clav / cephalosporin + macrolide OR fluoroquinolone
- Inpatient non-ICU: β-lactam + macrolide OR fluoroquinolone
- ICU: β-lactam + macrolide OR β-lactam + fluoroquinolone
- Pseudomonas: pip-tazo, cefepime, meropenem + AG/FQ
- MRSA: vanc or linezolid
Special Pathogens
- Legionella: hyponatremia, transaminitis, GI; urinary antigen serogroup 1
- Mycoplasma: cold agglutinins, bullous myringitis (rare)
- Klebsiella: alcoholic + currant jelly sputum
- Post-influenza S. aureus: post-viral pneumonia
CAPE COD (2023) â Hydrocortisone for Severe CAP
- 200 mg/d à 4-8 days
- â Mortality
- Class IIa
Procalcitonin
- High in bacterial, low in viral
- Stewardship (duration, initiation)
Vaccines (2024)
- PCV20 single dose adults ⥠19 high-risk or ⥠65
- PCV15 + PPSV23 alternative
- RSV ⥠60 + risk factors
- Annual influenza + COVID-19
Key Trials
- CAPE COD (2023): hydrocortisone for severe CAP â mortality
- PROCAP, PROHOSP, PROADAPT: procalcitonin reduces antibiotic exposure
- RECOVERY: dexamethasone for COVID
- REMAP-CAP: tocilizumab/baricitinib for severe COVID
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| Typical (Strep) |
Acute |
Productive |
Lobar consolidation |
β-lactam + macrolide |
| Atypical (Mycoplasma) |
Gradual |
Dry |
Patchy bilateral |
Macrolide or doxy |
| Legionella |
Severe |
Purulent |
Variable |
Levo or azithro |
| Aspiration |
Insidious |
Foul |
Dependent lobes |
Amox-clav or pip-tazo |
| Post-flu S. aureus |
After flu |
Bloody |
Cavitating |
Vanc + standard |
| Klebsiella |
Severe |
Currant jelly |
Upper lobe + cavity |
Cefepime + AG |
| PCP |
Subacute |
Dry |
Diffuse |
TMP-SMX + steroids |
Special Topics
âWalking Pneumoniaâ
- Mycoplasma + Chlamydia + Legionella + viral
- Younger, healthy
- Milder symptoms
- Atypical features
Switch IV to PO
- Clinically stable (improving signs)
- Tolerating PO
- Saves cost + hospital stay
- Discharge often within 24-48 hours after switch