125.2 📚 國考版

125.2.0.1 必背 Toxins (高頻考點)

Toxin	機轉 (一句記住)
Diphtheria	ADP-ribosylation EF-2
Tetanus	Block GABA/glycine → spastic
Botulinum	Block ACh → flaccid
Cholera	ADP-ribose Gs → cAMP ↑ → diarrhea
Shiga	60S ribosome → HUS
Pertussis	ADP-ribose Gi → cAMP ↑
Anthrax	Edema (EF) + Lethal (LF)
TSST-1	Superantigen (massive T cell)

125.2.0.2 必背 — 哪些細菌有 capsule (KENPNS / SHiNE SKiS)

• S. pneumoniae, K. pneumoniae, E. coli K1, N. meningitidis, H. influenzae b, Group B Strep, Salmonella typhi (Vi)

→ Asplenic 病人特別易感 (sepsis with encapsulated)

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