ð åèçïŒé«åž«åè / PGY OSCEïŒ
ð Cram Sheet
ð¥ é« yield 10
- Generalized LAP = CHICAGO
- Localized: çéšäœ + drainage
- Virchowâs left supraclavicular = gastric/abdominal ca
- B symptoms = lymphoma (fever + night sweats + weight loss)
- Excisional > FNA for suspected lymphoma
- Mono triad: pharyngitis + atypical lymph + LAP / HSM
- Massive spleno 4 ç
: CML, MF, lymphoma, kala-azar
- Howell-Jolly = asplenia
- Asplenia vaccine: pneumo + Hib + meningococcus
- EBV + amoxicillin = morbilliform rash (not allergy)
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| LAP biopsy threshold |
> 1-2 cm + > 4 wk |
| Massive spleno |
> 8 cm below costal |
| B symptom weight loss |
> 10% |
| Mono atypical lymph |
> 10% |
â é« yield
CHICAGO Generalized LAP
- Cancer (lymphoma, leukemia, mets)
- Hypersensitivity (DRESS, drug)
- Infection (HIV, EBV, CMV, TB, syph, toxo)
- CTD (SLE, RA, Stillâs)
- Atypical lymphoproliferative (Castleman)
- Granulomatous (sarcoid)
- Other (Kikuchi, Rosai-Dorfman)
Reed-Sternberg cell = Hodgkin
- Owl-eye appearance
- CD15 + CD30 +
- Subtypes: nodular sclerosis (most common), mixed cellularity, lymphocyte-rich, lymphocyte-depleted
NHL
- B-cell most common (DLBCL, follicular, MCL, MZL, Burkitt)
- T-cell less common
CLL
- Smudge cells
- Bilateral painless LAP + lymphocytosis
- Flow: CD5+ B cells (CD19+, CD20+)
Splenomegaly Workup
- Imaging confirms size
- BM biopsy if heme suspicion
- Smear (atypical lymph, hairy cell, schistocyte)
Splenectomy + Vaccines
- Pneumococcus (PCV20 + PPSV23)
- H. influenzae type b
- Meningococcus (ACWY + B)
- Annual flu
- å
ç«¥ antibiotic prophylaxis
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- CHICAGO? â Cancer/Hyper/Infection/CTD/Atypical/Granuloma/Other
- Virchowâs? â Left supraclavicular, gastric ca
- RS cell? â Hodgkin
- Mono triad? â Pharyngitis + LAP + atypical lymph
- Massive spleno? â CML, MF, lymphoma, kala-azar
- Asplenia smear? â Howell-Jolly
- Asplenia vaccines? â Pneumo + Hib + meningo
- Excisional vs FNA for lymphoma? â Excisional
- CLL flow markers? â CD5+, CD19+, CD20+
- Kikuchi disease? â Asian young female, self-limited cervical LAP + fever
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