202.4 📌 章末速蚘

  • Poxviridae: largest viruses, cytoplasmic replication (unique DNA virus)
  • Smallpox: eradicated 1980, bioterror Cat A, synchronous lesions, centrifugal
  • Mpox: 2022-2024 global Clade IIb (MSM), 2024 Clade Ib (DRC + neighboring, severe)
  • Reservoir: rodents (not actually monkeys despite name)
  • Synchronous lesion progression (like smallpox), LAP prominent
  • Treatment: tecovirimat STOMP 2024 NEGATIVE — compassionate use only
  • Vaccine: JYNNEOS (MVA-BN) non-replicating, 2 doses, PrEP/PEP, safe in immunocompromise
  • Mpox + HIV: severe in uncontrolled (CD4 < 200) — mortality 5-15%
  • Molluscum contagiosum: pearly umbilicated papules; children + STI; HIV → extensive
  • Orf / milker’s nodule: occupational sheep/cattle
  • 2024 PHEIC (WHO Aug 2024) for Clade Ib Mpox in Africa