67.3 🩺 內科專科考前版

67.3.0.1 📌 䞀頁重點

  • 22E: HES targeted therapy, gene therapy CGD emerging
  • Taiwan: 抗甲狀腺藥 agranulocytosis è­Šå‘Š

67.3.0.2 🌟 Pearls (8)

  1. CGD HSCT for young patients
  2. HES FIP1L1-PDGFRA → imatinib 100% response
  3. Mepolizumab (anti-IL-5) for HES + EGPA
  4. Clozapine REMS weekly CBC required
  5. Methimazole > PTU in routine (PTU only 1st trimester pregnancy + thyroid storm)
  6. Felty’s rituximab emerging
  7. MDS hypocellular vs aplastic anemia
  8. Schwachman-Diamond: pancreatic + neutropenia (rare congenital)

67.3.0.3 📍 Taiwan

  • 健保 G-CSF for chemo-induced neutropenia
  • 抗甲狀腺藥 monitoring 嚎栌
  • HSCT capacity at major centers

67.3.0.4 🎓 內專重點

  1. Neutropenia 分玚 + workup
  2. CGD/LAD/Chediak-Higashi
  3. Drug-induced
  4. HES + FIP1L1-PDGFRA
  5. Felty’s

⚠ AI 草皿。