381 Ch 380. Atypical Parkinsonism (MSA, PSP, CBD)

Atypical parkinsonism = parkinsonism + additional features that distinguish from idiopathic PD; poor levodopa response often；synucleinopathies (α-syn) = PD + DLB + MSA (multiple system atrophy); tauopathies (4R tau) = PSP (progressive supranuclear palsy) + CBD (corticobasal degeneration) + FTD-tau；MSA: parkinsonian (MSA-P) vs cerebellar (MSA-C) subtypes + severe autonomic failure (orthostatic hypotension, urinary, sexual) + inspiratory stridor + REM sleep behavior + poor levodopa response；PSP: vertical supranuclear gaze palsy (especially downgaze) + early falls (within 1 year) + axial rigidity + frontal cognitive + Richardson syndrome (classic) + variants (PSP-P, PSP-PGF, PSP-CBS, PSP-SL); CBD: asymmetric parkinsonism + alien limb phenomenon + cortical sensory loss + apraxia + myoclonus + dystonia；no disease-modifying therapy for any — supportive care multidisciplinary。