149.2 📚 國考版

149.2.0.1 必背 — Time vs Concentration Dependent

• Time (T > MIC): β-lactam, vancomycin — multiple doses / continuous infusion
• Concentration (Cmax/MIC): aminoglycoside, fluoroquinolone — once daily
• AUC/MIC: vancomycin (newer), linezolid

149.2.0.2 必背 — Bactericidal

• β-lactam, vancomycin, aminoglycoside, fluoroquinolone, daptomycin, fosfomycin, metronidazole, TMP-SMX (synergistic), rifampin

149.2.0.3 必背 — Bacteriostatic

• Macrolide, tetracycline, clindamycin, linezolid, chloramphenicol, sulfa (monotherapy)

149.2.0.4 必背 — Spectrum Notes

• Aztreonam: GN only — good for PCN allergy
• Cefazolin: 1st gen — gold for surgical prophy + MSSA
• Daptomycin: NOT for pneumonia (surfactant inactivation)
• Clindamycin / Fluoroquinolone: highest C. diff risk
• TMP-SMX: PJP + Nocardia + Stenotrophomonas; SJS risk

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