248 Ch 248. Paracoccidioidomycosis + Talaromycosis

Paracoccidioidomycosis (S. American blastomycosis): Paracoccidioides brasiliensis — Latin America endemic; adult males with extensive mucosal + pulmonary disease; itraconazole. Talaromycosis (formerly Penicillium marneffei): Talaromyces marneffei — SE Asia (Vietnam, Thailand, S China) + HIV CD4 < 100 common; bamboo rats reservoir; umbilicated skin lesions + fever + hepatosplenomegaly + amphotericin B → itraconazole。