232 Ch 232. Toxoplasmosis

Toxoplasma gondii — cat-borne intracellular protozoan; ubiquitous (~ 30-50% adults seropositive globally); congenital toxoplasmosis (chorioretinitis + hydrocephalus + calcifications) + HIV reactivation (encephalitis CD4 < 100) are major clinical concerns; immunocompetent acquired: mostly asymptomatic / mononucleosis-like; sulfadiazine + pyrimethamine + leucovorin = first-line。