216 Ch 216. HIV — Epidemiology, Virology, Pathogenesis

Retrovirus pandemic since 1981; 39M living with HIV globally; 1.3M new infections + 630K AIDS deaths/yr (2023 UNAIDS); U=U paradigm (undetectable = untransmittable); PrEP revolution (oral + injectable); pediatric vertical transmission reduced > 95% with maternal ART; 2030 UNAIDS 95-95-95 target (95% diagnosed, 95% on ART, 95% virologically suppressed); functional cure cases (Berlin/London/Düsseldorf/NYC patients); CCR5Δ32 stem cell transplants。