192.4 📌 章末速蚘

  • RIPE: Rifampin, INH, PZA, Ethambutol — 1st-line
  • R Rifampin: orange, CYP3A4 inducer, hepatotoxic
  • I INH: mycolic acid, hepatotoxic, peripheral neuropathy → B6
  • P PZA: most hepatotoxic, hyperuricemia
  • E Ethambutol: optic neuritis → monthly visual + color check
  • Pyridoxine 25-50 mg/d always with INH
  • 2024 WHO 4-month regimen: rifapentine + moxifloxacin + INH + PZA for drug-sensitive non-cavitary
  • BPaL / BPaLM = bedaquiline + pretomanid + linezolid ± moxifloxacin × 6 mo for MDR / Pre-XDR / XDR
  • Bedaquiline — ATP synthase inhibitor, QTc, MDR cornerstone
  • GeneXpert MTB/RIF — rapid rifampin R detection + TB
  • HIV + TB: rifampin + ART interactions → rifabutin alt
  • DOT / vDOT standard for active TB