67.2 📚 國考版醫垫國考 / PGY OSCE

67.2.0.1 📌 Cram Sheet

67.2.0.1.1 🔥 高 yield 10
  1. Neutropenia 分玚 ANC 1.5/0.5/0.2
  2. Neutropenic fever ANC < 500 + T ≥ 38.3 → < 1 hr antibiotic
  3. CGD = NADPH oxidase + catalase + 现菌 (Staph, Burkholderia, Aspergillus, Nocardia)
  4. CGD 治療: TMP-SMX + itraconazole + IFN-γ
  5. LAD = late umbilical cord separation
  6. Chediak-Higashi: 郚分癜化 + giant granules
  7. NAACP eosinophilia: Neoplastic, Allergy, Addison, CTD, Parasites
  8. HES FIP1L1-PDGFRA → imatinib
  9. Methimazole / PTU 副䜜甚: agranulocytosis
  10. Felty’s: RA + neutropenia + splenomegaly
67.2.0.1.2 🔢 必背
項目 æ•žå­—
ANC severe < 500
ANC profound < 200
HES eosinophilia > 1,500 + organ
Neutropenic fever T ≥ 38.3

67.2.0.2 ⭐ 高 yield

67.2.0.2.1 Drug-Induced Neutropenia
  • 化療 / 茻射
  • Antibiotic (vanco, β-lactam, sulfa, linezolid)
  • Antithyroid (methimazole, PTU) → è­Šå‘Š agranulocytosis
  • Antipsychotic (clozapine — weekly CBC required)
  • Anti-epileptic (CBZ, valproate)
  • NSAID, gold, DMARDs
67.2.0.2.2 Neutrophil Function Disorders
病 機蜉 感染類型
CGD NADPH oxidase Catalase + (Staph, Burkholderia, Aspergillus, Nocardia, Serratia)
LAD-1 β2 integrin 反芆现菌、no pus, late umbilical cord separation
Chediak-Higashi LYST (lysosomal traffic) 反芆现菌、albinism、神經
MPO def Myeloperoxidase Candida (in DM)
67.2.0.2.3 Eosinophilia NAACP
  • Neoplastic
  • Allergy
  • Addison
  • CTD (EGPA)
  • Parasites
67.2.0.2.4 Felty’s Triad
  • RA + neutropenia + splenomegaly

67.2.0.3 🎯 自我檢枬

  1. ANC severe? → < 500
  2. CGD 機蜉? → NADPH oxidase
  3. CGD 感染類型? → Catalase + (Staph, Burkholderia, Aspergillus, Nocardia)
  4. LAD signature? → Late umbilical cord separation
  5. NAACP? → Neoplastic, Allergy, Addison, CTD, Parasites
  6. HES driver? → FIP1L1-PDGFRA fusion
  7. HES treatment? → Imatinib
  8. Felty’s? → RA + neutropenia + splenomegaly
  9. Methimazole monitoring? → CBC for agranulocytosis
  10. Clozapine monitoring? → Weekly CBC

⚠ AI 草皿。