244 Ch 244. Cryptococcosis

Encapsulated yeast; C. neoformans (worldwide, immunocompromise, HIV/AIDS) + C. gattii (tropical/sub-tropical + Pacific NW + Vancouver Island; sometimes immunocompetent severe); major cause of HIV-related meningitis worldwide (especially Africa); liposomal amphotericin B + flucytosine induction → fluconazole consolidation/maintenance; repeated LP for ICP; delay ART 4-6 wk (COAT trial)。