201.4 📌 章末速蚘

  • HHV-6: roseola (3-5d fever → trunk rash), #1 febrile seizure cause this age, β-subfamily
  • HHV-6 HSCT encephalitis (limbic, SIADH) — foscarnet / ganciclovir
  • ciHHV-6 (1% population) — chromosomal integration, not active infection
  • DRESS with allopurinol/anticonvulsants — HHV-6 reactivation
  • HHV-8 (KSHV): Kaposi’s Sarcoma (classic / endemic / iatrogenic / AIDS-related), PEL (body cavity effusions), MCD (Castleman), KICS (ICU severe)
  • AIDS KS: ART + chemotherapy (PEG-liposomal doxorubicin / paclitaxel)
  • Transplant KS: switch to mTOR inhibitor (sirolimus / everolimus)
  • MCD: rituximab primary; siltuximab (anti-IL-6)
  • LANA-1 IHC = HHV-8 diagnostic
  • 6th disease (HHV-6) vs 5th disease (parvovirus B19) — don’t confuse